Herbal Medicine Alters Genes, Cell Mitosis and Epigenome

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Herbal Medicine Alters Genes, Cell Mitosis and Epigenome

Posted: 09 Nov 2013 01:27 AM PST

Genetics researchers from Taiwan's National Central University have determined that over a third of herbal medicines used in Traditional Chinese Medicine - and nearly all leading therapeutic herbs - alter our genes or alter enzymes that alter our genetic material.

The researchers analyzed 3,294 traditional Chinese medicines – combinations of herbs – and found that 1,170 or 36% will interact with enzymes that alter the histones that lie within our chromosome material.

And of those that interact with or modify those enzymes, 56% will promote what is called chromatin condensation.

Chromatin is the complex of DNA and protein material that our cells' nucleus is made of. Through the histone enzymes, chromatin will bind up and prepare for cell division, allowing a copy of our DNA to be made during mitosis.

Chromatin condensation occurs during the cell's reproductive cycle – as cells divide. During the interphase step the chromatin is loosely mixed, and then during the prophase step the chromatin will condense and the chromosomes will become visible to microscopic observation. This condensed state continues one through the next stages of mitosis until the cell successfully divides.
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